The Merivale Bridge is a double track railway bridge crossing the Brisbane River. It crosses the Milton Reach of the river, located in between the Go Between Bridge and the William Jolly Bridge. Exclusively a railway crossing, it is located between the stations of South Brisbane and Roma Street, linking the northern and southern elements of the Queensland Rail City network. The Merivale Bridge is the only inner-city rail crossing in Brisbane. By 2016 it was expected to be over capacity, leading the Queensland Government to announce the Cross River Rail project.

The Brisbane River is the longest river in South East Queensland, Australia, and flows through the city of Brisbane, before emptying into Moreton Bay on the Coral Sea. John Oxley, the first European to explore the river, named it after the Governor of New South Wales, Sir Thomas Brisbane in 1823. The penal colony of Moreton Bay later adopted the same name, eventually becoming the present city of Brisbane. The river is a tidal estuary and the water is brackish from its mouth through the majority of the Brisbane metropolitan area westward to the Mount Crosby Weir. The river is wide and navigable throughout the Brisbane metropolitan area.