Merseburg Cathedral is the proto-cathedral of the former Bishopric of Merseburg in Merseburg, Germany. The mostly Gothic church is considered an artistic and historical highlight in southern Saxony-Anhalt.

The Bishopric of Merseburg was an episcopal see on the eastern border of the medieval Duchy of Saxony with its centre in Merseburg, where Merseburg Cathedral was constructed. The see was founded in 967 by Emperor Otto I at the same time in the same manner as those of Meissen and Zeitz, all suffragan dioceses of the Archbishopric of Magdeburg as part of a plan to bind the adjacent Slavic ("Wendish") lands in the Saxon Eastern March beyond the Saale River more closely to the Holy Roman Empire.