The Metallurgical Laboratory was a scientific laboratory at the University of Chicago that was established in February 1942 to study and use the newly discovered chemical element plutonium. It researched plutonium's chemistry and metallurgy, designed the world's first nuclear reactors to produce it, and developed chemical processes to separate it from other elements. In August 1942 the lab's chemical section was the first to chemically separate a weighable sample of plutonium, and on 2 December 1942, the Met Lab produced the first controlled nuclear chain reaction, in the reactor Chicago Pile-1, which was constructed under the stands of the university's old football stadium, Stagg Field.

Amos Alonzo Stagg Field is the name of two successive football fields for the University of Chicago. Beyond sports, the first Stagg Field (1893–1957), named for famed coach, Alonzo Stagg, is remembered for its role in a landmark scientific achievement of Enrico Fermi and the Metallurgical Laboratory during the Manhattan Project. The site of the first artificial nuclear chain reaction, which occurred within the field's west viewing-stands structure, received designation as a National Historic Landmark on February 18, 1965. On October 15, 1966, which is the day that the National Historic Preservation Act of 1966 was enacted creating the National Register of Historic Places, it was added to that as well. The site was named a Chicago Landmark on October 27, 1971.