The Metropolitan and Great Central Joint Railway was a joint railway company that controlled a line extending from Harrow on the Hill in what is now north-western Greater London to Verney Junction in Buckinghamshire, England. Owned by the Metropolitan Railway and the Great Central Railway, the railway was nationalised in 1948.

The Great Central Railway in England was formed when the Manchester, Sheffield and Lincolnshire Railway changed its name in 1897, anticipating the opening in 1899 of its London Extension. On 1 January 1923, the company was grouped into the London and North Eastern Railway.