Michele Lee is an American actress, singer, dancer, producer and director. She is known for her role as Karen Fairgate MacKenzie on the prime-time soap opera Knots Landing, for which she was nominated for a 1982 Emmy Award and won the Soap Opera Digest Award for Best Actress in 1988, 1991, and 1992. She was the only performer to appear in all 344 episodes of the series.

Karen MacKenzie is a long-running fictional character in the CBS primetime soap opera Knots Landing. Karen is portrayed by actress Michele Lee, and has appeared on the show since its pilot episode, first broadcast on December 27, 1979. Knots Landing follows the trials of four middle-class families living on a suburban cul-de-sac known as Seaview Circle in California. Lee portrayed Karen for the entire run of Knots Landing, being the sole cast member to appear in every episode of its fourteen seasons. At the time, her appearances in all 344 episodes set a record for an actress on American primetime television. Karen's storylines focus on family troubles, business dealings, addiction and kidnapping.