Michilimackinac is derived from an Ottawa Ojibwe name for present-day Mackinac Island and the region around the Straits of Mackinac between Lake Huron and Lake Michigan. Early settlers of North America applied the term to the entire region along Lakes Huron, Michigan, and Superior. Today it is considered to be mostly within the boundaries of Michigan, in the United States. Michilimackinac was the original name for present day Mackinac Island and Mackinac County.

Mackinac Island is an island and resort area, covering 4.35 square miles (11.3 km2) in land area, in the U.S. state of Michigan. The name of the island in Odawa is Michilimackinac and "Mitchimakinak" in Ojibwemowin, meaning "Great Turtle". It is located in Lake Huron, at the eastern end of the Straits of Mackinac, between the state's Upper and Lower Peninsulas. The island was long home to an Odawa settlement and previous indigenous cultures before European colonization began in the 17th century. It was a strategic center of the fur trade around the Great Lakes. Based on a former trading post, Fort Mackinac was constructed on the island by the British during the American Revolutionary War. It was the site of two battles during the War of 1812 before the northern border was settled and the US gained this island in its territory.