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DNA strand slippage during replication of an STR locus. Boxes symbolize repetitive DNA units. Arrows indicate the direction in which a new DNA strand
DNA strand slippage during replication of an STR locus. Boxes symbolize repetitive DNA units. Arrows indicate the direction in which a new DNA strand (white boxes) is being replicated from the template strand (black boxes). Three situations during DNA replication are depicted. (a) Replication of the STR locus has proceeded without a mutation. (b) Replication of the STR locus has led to a gain of one unit owing to a loop in the new strand; the aberrant loop is stabilized by flanking units complementary to the opposite strand. (c) Replication of the STR locus has led to a loss of one unit owing to a loop in the template strand. (Forster et al. 2015)
A partial human STR profile obtained using the Applied Biosystems Identifiler kit
A partial human STR profile obtained using the Applied Biosystems Identifiler kit
Restriction Fragment Length Polymorphism
Restriction Fragment Length Polymorphism
CBP chemist reads a DNA profile to determine the origin of a commodity.
CBP chemist reads a DNA profile to determine the origin of a commodity.