Middletown was the main station along the Erie Railroad mainline in the city of Middletown, New York. Located on Depot Street, the station was first opened in 1843 with the construction of the New York, Lake Erie and Western Railroad, which had originally terminated at Goshen. The station was located along the New York Division, which stretched from Pavonia Terminal in Jersey City, New Jersey, to the Sparrowbush station just north of Port Jervis.

Middletown is the largest city in Orange County, New York, United States. It lies in New York's Hudson Valley region, near the Wallkill River and the foothills of the Shawangunk Mountains. Middletown is situated between Port Jervis and Newburgh, New York. At the 2020 United States census, the city's population was 30,345, reflecting an increase of 2,259 from the 28,086 counted in the 2010 census. The ZIP Code is 10940. Middletown falls within the Kiryas Joel–Poughkeepsie–Newburgh Metropolitan Statistical Area, which belongs to the larger New York–Newark–Bridgeport, NY–NJ–CT–PA Combined Statistical Area.