Minnesota State Highway 74 (MN 74) is a 34.956-mile-long (56.256 km) highway in southeast Minnesota that runs from its intersection with U.S. Highway 52 and State Highway 30 in Chatfield and continues north to its northern terminus at its intersection with U.S. Highway 61 at Weaver along the Mississippi River. It is the only remaining road in the state highway system that is still partially unpaved.

U.S. Highway 52 (US 52) enters the state of Minnesota at the unincorporated community of Prosper, north of the town of Burr Oak, Iowa. The route is marked north–south in Minnesota along its independent segment from the Iowa state line to downtown St. Paul. US 52 is not signed along the length of its concurrency with Interstate 94 (I-94) from downtown St. Paul to the North Dakota state line at Moorhead and Fargo.