A missile combat crew (MCC), is a team of highly trained specialists, often called missilemen, or missileers, staffing Intermediate Range and Intercontinental ballistic missile systems. In the United States, personnel, officially coded as Nuclear and Missile Operations Officers, of the United States Air Force, operate underground missile systems at launch control centers located throughout the country. There are also a select few missileers that have the chance to become part of a Missile Combat Crew-Airborne (MCC-A) operating the Airborne Launch Control System which provides a survivable launch capability for the Minuteman ICBM force. Crew size varies among the different missile systems, but the number is always greater than one, to abide by USSTRATCOM's two-man rule for positive control of nuclear weapons.

The United States Air Force (USAF) is the air service branch of the United States Armed Forces, and is one of the eight uniformed services of the United States. Originally created on 1 August 1907, as a part of the United States Army Signal Corps, the USAF was established as a separate branch of the United States Armed Forces in 1947 with the enactment of the National Security Act of 1947. It is the second youngest branch of the United States Armed Forces and the fourth in order of precedence. The United States Air Force articulates its core missions as air supremacy, global integrated intelligence, surveillance and reconnaissance, rapid global mobility, global strike, and command and control.