Mission Bay is an artificial, saltwater bay located south of the Pacific Beach community of San Diego, California created from approximately 2,000 acres (810 ha) of historical wetland, marsh, and saltwater bay habitat. The bay is part of the recreational Mission Bay Park, the largest man-made aquatic park in the United States, consisting of 4,235 acres (17.14 km2), approximately 46% land and 54% water. The combined area makes Mission Bay Park the ninth largest municipally-owned park in the United States.

San Diego is a city on the Pacific Ocean coast in Southern California located immediately adjacent to the Mexico–United States border. With a population of over 1.3 million residents, the city is the eighth-most populous in the United States and the second-most populous in the state of California after Los Angeles. The city is the seat of San Diego County, which has a population of nearly 3.3 million people as of 2021. San Diego is known for its mild year-round Mediterranean climate, extensive beaches and parks, its long association with the United States Navy, and its recent emergence as a healthcare and biotechnology development center.