Mission Santa Clara de Asís is a Spanish mission in the city of Santa Clara, California. The mission, which was the eighth in California, was founded on January 12, 1777, by the Franciscans. Named for Saint Clare of Assisi, who founded the order of the Poor Clares and was an early companion of St. Francis of Assisi, this was the first California mission to be named in honor of a woman.

Santa Clara is a city in the county of the same name. The city's population was 127,647 at the 2020 census, making it the eighth-most populous city in the Bay Area. Located in the southern Bay Area, the city was founded by the Spanish in 1777 with the establishment of Mission Santa Clara de Asís under the leadership of Junípero Serra.