Mississippi Highway 182 designates the old two-lane highway for U.S. Route 82 (US 82) where the current US 82 occupies a new right-of-way. Some of the towns with a segment of MS 182 are Winona, Kilmichael, Eupora, Mayhew, Starkville, and Columbus.

U.S. Route 82 is a section of a west-east highway that travels through Mississippi. It starts at the Arkansas state line at Refuge and ends at the Alabama state line east of Columbus.