The Mitscher-class destroyer was an experimental destroyer class of four ships that were built for the United States Navy shortly after World War II. Considerably larger than all previous destroyers, but smaller than their immediate predecessor, the experimental Norfolk, they would have been the first post-war destroyer class had they not been reclassified during construction as destroyer leaders (DL). Commissioned in 1953–1954, two of the class served until 1969, and were scrapped in the 1970s. The other two were converted into guided missile destroyers (DDG), served until 1978, and were sold for scrap by 1980.

The second USS Norfolk (DL-1) was the first destroyer leader of the United States Navy. Originally projected as a hunter-killer cruiser, she was in service until 1970, and was scrapped in 1974.