Mole Creek is a town in the upper Mersey Valley, in the central north of Tasmania, Australia. Mole Creek is well known for its honey and accounts for about 35 percent of Tasmania's honey production. The locality is in the Meander Valley Council area, but with about 3% in the Kentish Council LGA.

Meander Valley Council is a local government body in northern Tasmania. It covers the western outskirts of Launceston, and further westward along the Meander River. Meander Valley Council is classified as a rural local government area and has a population of 19,713. Major towns and localities of the region include Elizabeth Town, Mole Creek, Westbury and the principal town of Deloraine.