Monticello is a college town in, and the county seat of, Drew County, Arkansas. As of the 2010 census it had a population of 9,467. Founded in 1849 in the Arkansas Timberlands near the Arkansas Delta region, the city has long been a commercial, cultural and educational hub for southeast Arkansas. With a historically agriculture- and silviculture-based economy, it has diversified to include growth from the medical sector and the University of Arkansas at Monticello.

Drew County is a county located in the southeast region of the U.S. state of Arkansas. As of the 2020 census, the population was 17,350. The county seat and largest city is Monticello. Drew County was formed on November 26, 1846, and named for Thomas Drew, the third governor of Arkansas.