Mosè in Egitto is a three-act opera written by Gioachino Rossini to an Italian libretto by Andrea Leone Tottola, which was based on a 1760 play by Francesco Ringhieri, L'Osiride. It premièred on 5 March 1818 at the recently reconstructed Teatro San Carlo in Naples, Italy.

Gioachino Antonio Rossini was an Italian composer who gained fame for his 39 operas, although he also wrote many songs, some chamber music and piano pieces and some sacred music. He set new standards for both comic and serious opera before retiring from large-scale composition while still in his thirties, at the height of his popularity.