Moses Taft 2nd was born at Uxbridge, Massachusetts. He was significant as an early American Industrialist and financier in the historic Blackstone Valley, and a member of the Taft family.

Uxbridge is a town in Worcester County, Massachusetts, United States, first colonized in 1662 and incorporated in 1727. It was originally part of the town of Mendon, and named for the Earl of Uxbridge. The town is located 36 mi (58 km) southwest of Boston and 15 mi (24 km) south-southeast of Worcester, at the midpoint of the Blackstone Valley National Historic Park. The historical society notes that Uxbridge is the "Heart of The Blackstone Valley" and is also known as "the Cradle of the Industrial Revolution". Uxbridge was a prominent Textile center in the American Industrial Revolution. Two Quakers served as national leaders in the American anti-slavery movement. Uxbridge "weaves a tapestry of early America".