The Muisca agriculture describes the agriculture of the Muisca, the advanced civilisation that was present in the times before the Spanish conquest on the high plateau in the Colombian Andes; the Altiplano Cundiboyacense. The Muisca were a predominantly agricultural society with small-scale farmfields, part of more extensive terrains. To diversify their diet, they traded mantles, gold, emeralds and salt for fruits, vegetables, coca, yopo and cotton cultivated in lower altitude warmer terrains populated by their neighbours, the Muzo, Panche, Guane, Guayupe, Lache, Sutagao and U'wa. Trade of products grown farther away happened with the Calima, Pijao and Caribbean coastal communities around the Sierra Nevada de Santa Marta.

The Guayupe are an Arawak-speaking indigenous group of people in modern-day Colombia. They inhabit the westernmost parts of the department of Meta. At the time of the Spanish conquest, more than 250,000 Guayupe were living in large parts of Meta.