Mule Bone: A Comedy of Negro Life is a 1930 play by American authors Langston Hughes and Zora Neale Hurston. The process of writing the play led Hughes and Hurston, who had been close friends, to sever their relationship. Mule Bone was not staged until 1991, when it was produced in New York City by the Lincoln Center Theater.

Zora Neale Hurston was an American author, anthropologist, and documentary filmmaker. She portrayed racial struggles in the early-20th-century American South and published research on hoodoo and Caribbean Vodou. The most popular of her four novels is Their Eyes Were Watching God, published in 1937. She also wrote more than 50 short stories, plays, and essays.