Murder Bay was a disreputable slum in Washington, D.C., roughly bounded by Constitution Avenue NW, Pennsylvania Avenue NW, and 13th and 15th Streets NW. The area was a center of crime through the early 20th century, with an extensive criminal underclass and prostitution occurring in several brothels and hotels in the area. The area was completely rebuilt during the construction of the Federal Triangle project in the late 1920s and 1930s.

The William Jefferson Clinton Federal Building is a complex of several historic buildings located in the Federal Triangle in Washington, D.C., across 12th Street, NW from the Old Post Office. The complex now houses the headquarters of the Environmental Protection Agency (EPA).