Mutation rate
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In genetics, the mutation rate is the frequency of new mutations in a single gene, nucleotide sequence, or organism over time. Mutation rates are not constant and are not limited to a single type of m
Transitions (Alpha) and transversions (Beta).
Microsatellite
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A microsatellite is a tract of repetitive DNA that consists of a particular sequence of base pairs repeated a large number of times. Microsatellites occur at thousands of locations within an organism'
DNA strand slippage during replication of an STR locus. Boxes symbolize repetitive DNA units. Arrows indicate the direction in which a new DNA strand (white boxes) is being replicated from the template strand (black boxes). Three situations during DNA replication are depicted. (a) Replication of the STR locus has proceeded without a mutation. (b) Replication of the STR locus has led to a gain of one unit owing to a loop in the new strand; the aberrant loop is stabilized by flanking units complementary to the opposite strand. (c) Replication of the STR locus has led to a loss of one unit owing to a loop in the template strand. (Forster et al. 2015)
A partial human STR profile obtained using the Applied Biosystems Identifiler kit