The Mylapore Clique or oligarchy was a small coterie, amounting to a "handful" of politically moderate, elite Brahmins, primarily Tamil Brahmins, many of them noted lawyers, administrators, academics or educators, or industrialists, in the Madras Presidency, who 'wielded almost exclusive influence and patronage in the service and government appointments', 'controlled the flow of resources out of the institutions of the capital' and 'dominated the professional and political life of [the presidency].' Informal and exclusive, it was historically controlled by two extended families, the Vembaukum Iyengars, and the Calamur Viravalli-Chetpet Iyers, and took its name from the luxurious Madras City neighborhood in which many leading members kept mansions. The clique coalesced and began its dominance in the 1880s and 1890s under the headship of Sir V. Bhashyam Aiyangar and Sir S. Subramania Iyer, with R. Raghunatha Rao as a tertiary leader; while some argue that it reached its zenith between 1910 and 1920, others highlight its remarkable successes in ministry and magistracy continuing in the 1920s and 1930s, with Sir C. P. Ramaswami Iyer as leader.

Mylapore, or Thirumayilai, is a neighbourhood in the central part of the city of Chennai, India. It is one of the oldest residential parts of the city. The locality is claimed to be the birthplace of the celebrated Tamil philosopher Valluvar, and the Hindu saint and philosopher, Peyalvar.