Mysia was a region in the northwest of ancient Asia Minor. It was located on the south coast of the Sea of Marmara. It was bounded by Bithynia on the east, Phrygia on the southeast, Lydia on the south, Aeolis on the southwest, Troad on the west, and the Propontis on the north. In ancient times it was inhabited by the Mysians, Phrygians, Aeolian Greeks and other groups.

Pergamon or Pergamum, also referred to by its modern Greek form Pergamos (Πέργαμος), was a rich and powerful ancient Greek city in Mysia. It is located 26 kilometres (16 mi) from the modern coastline of the Aegean Sea on a promontory on the north side of the river Caicus and northwest of the modern city of Bergama, Turkey.