The NHS Nightingale Hospital London was the first of the NHS Nightingale Hospitals, temporary hospitals set up by NHS England for the COVID-19 pandemic. It was housed in the ExCeL London convention centre in East London. The hospital was rapidly planned and constructed, being formally opened on 3 April and receiving its first patients on 7 April 2020. It served 54 patients during the first wave of the pandemic, and was used to serve non-COVID patients and provide vaccinations during the second wave. It was closed in April 2021.

The NHS Nightingale Hospital Birmingham was the second of the temporary NHS Nightingale Hospitals set up by NHS England to help to deal with the COVID-19 pandemic. It was constructed inside the National Exhibition Centre, Solihull, and opened on 16 April 2020. It cost £66.4 million to set up and was the most expensive of all the Nightingale temporary hospitals. On 1 April 2021 the hospital closed without ever treating a patient.