NMDA receptor
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The N-methyl-D-aspartate receptor is a glutamate receptor and a predominantly Ca2+ ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other tw
NR2 subunit in vertebrates (left) and invertebrates (right). Ryan et al., 2008
Figure 4: The chemical structures of MK-801, phencyclidine and ketamine, high affinity uncompetitive NMDA receptor antagonists
Figure 5: Chemical structures of memantine (right) and amantadine (left)
Figure 8: Structure activity relationship (SAR) of amantadine and related compounds
NMDA receptor antagonist
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NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the N-methyl-D-aspartate receptor. They are commonly used as anesthetics for humans and animals; the s
NMDA receptor
…other causes) may be involved in impairment of synaptic plasticity and could have other negative repercussions. The main problem with the utilization of NMDA receptor antagonists for neuroprotection is that the physiological actions of the NMDA receptor are essential for normal neuronal function. To be clinically useful NMDA…
Ketamine, one of the most popular NMDA receptor antagonists