NMDA receptor antagonist
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NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the N-methyl-D-aspartate receptor. They are commonly used as anesthetics for humans and animals; the s
Ketamine, one of the most popular NMDA receptor antagonists
NMDA receptor
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The N-methyl-D-aspartate receptor is a glutamate receptor and a predominantly Ca2+ ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other tw
NMDA receptor antagonist
…NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the N-methyl-D-aspartate receptor (NMDAR). They are commonly used as anesthetics for humans and animals; the state of anesthesia they induce is referred to as dissociative anesthesia. Several…
NR2 subunit in vertebrates (left) and invertebrates (right). Ryan et al., 2008
Figure 4: The chemical structures of MK-801, phencyclidine and ketamine, high affinity uncompetitive NMDA receptor antagonists
Figure 5: Chemical structures of memantine (right) and amantadine (left)
Figure 8: Structure activity relationship (SAR) of amantadine and related compounds