Naqiʾa or Naqia (Akkadian: Naqīʾa, also known as Zakūtu, was a wife of the Assyrian king Sennacherib and the mother of his son and successor Esarhaddon. Naqiʾa is the best documented woman in the history of the Neo-Assyrian Empire and she reached an unprecedented level of prominence and public visibility; she was perhaps the most influential woman in Assyrian history. She is one of the few ancient Assyrian women to be depicted in artwork, to commission her own building projects, and to be granted laudatory epithets in letters by courtiers. She is also the only known ancient Assyrian figure other than kings to write and issue a treaty.

Sennacherib was the king of the Neo-Assyrian Empire from the death of his father Sargon II in 705 BC to his own death in 681 BC. The second king of the Sargonid dynasty, Sennacherib is one of the most famous Assyrian kings for the role he plays in the Hebrew Bible, which describes his campaign in the Levant. Other events of his reign include his destruction of the city of Babylon in 689 BC and his renovation and expansion of the last great Assyrian capital, Nineveh.