Sennacherib was the king of the Neo-Assyrian Empire from the death of his father Sargon II in 705 BC to his own death in 681 BC. The second king of the Sargonid dynasty, Sennacherib is one of the most famous Assyrian kings for the role he plays in the Hebrew Bible, which describes his campaign in the Levant. Other events of his reign include his destruction of the city of Babylon in 689 BC and his renovation and expansion of the last great Assyrian capital, Nineveh.

The Neo-Assyrian Empire was the fourth and penultimate stage of ancient Assyrian history. Beginning with the accession of Adad-nirari II in 911 BC, the Neo-Assyrian Empire grew to dominate the ancient Near East throughout much of the 8th and 7th centuries BC, becoming the largest empire in history up to that point. Because of its geopolitical dominance and ideology based in world domination, the Neo-Assyrian Empire is by many researchers regarded to have been the first world empire in history. It influenced other empires of the ancient world culturally, administratively, and militarily, including the Babylonians, the Achaemenids, and the Seleucids. At its height, the empire was the strongest military power in the world and ruled over all of Mesopotamia, the Levant and Egypt, as well as parts of Anatolia, Arabia and modern-day Iran and Armenia.