Nathan Appleton was an American merchant and politician and a member of the group of entrepreneurs known as "The Boston Associates".

The Boston Associates were a loosely linked group of investors in 19th-century New England. They included Nathan Appleton, Patrick Tracy Jackson, Abbott Lawrence, and Amos Lawrence. Often related directly or through marriage, they were based in Boston, Massachusetts. The term "Boston Associates" was coined by historian and professor of economics and Marxism, Vera Shlakman in her 1935 work, Economic History of a Factory Town, A Study of Chicopee, Massachusetts.