There are 21 protected areas of the United States designated as national preserves. They were established by an act of Congress to protect areas that have resources often associated with national parks but where certain natural resource-extractive activities such as hunting and mining may be permitted, provided their natural values are preserved. The activities permitted in each national preserve vary depending on the enabling legislation of the unit. All national preserves are managed by the National Park Service (NPS) as part of the National Park System.

The protected areas of the United States are managed by an array of different federal, state, tribal and local level authorities and receive widely varying levels of protection. Some areas are managed as wilderness, while others are operated with acceptable commercial exploitation. As of 2022, the 42,826 protected areas covered 1,235,486 km2 (477,024 sq mi), or 13 percent of the land area of the United States. This is also one-tenth of the protected land area of the world. The U.S. also had a total of 871 National Marine Protected Areas, covering an additional 1,240,000 sq mi (3,200,000 km2), or 26 percent of the total marine area of the United States.