Nationwide Children's Hospital is a nationally ranked pediatric acute care teaching hospital located in the Southern Orchards neighborhood of Columbus, Ohio. The hospital has 673 pediatric beds and is affiliated with the Ohio State University College of Medicine. The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout Ohio and surrounding regions. Nationwide Children's Hospital also sometimes treats adults that require pediatric care. Nationwide Children's Hospital also features an ACS-verified Level 1 Pediatric Trauma Center, one of four in the state. The hospital has affiliations with the nearby Ohio State University Wexner Medical Center. Nationwide Children's Hospital is located on its own campus and has more than 1,379 medical staff members and over 11,909 total employees.

Southern Orchards is an established neighborhood near the south side of Columbus, Ohio. It is located immediately southeast of downtown and is the 23rd most walkable neighborhood in Columbus with 3,538 residents. The neighborhood is the target of revitalization and beautification largely due to its anchor institution Nationwide Children's Hospital and a renewed interest in urban living in the city's core. Since 2008, more than 90 properties have been improved through the hospital’s Healthy Homes program and continued revitalization is occurring along the major streets of Livingston and Parsons Avenues as the city moves to reconnect downtown to its surrounding neighborhoods.