Neprilysin is an enzyme that in humans is encoded by the MME gene. Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates severa
Neprilysin immunohistochemical staining of normal kidney.
Immunohistochemistry of CD10 in the germinal center of a normal tonsil, conferring membranous staining of germinal-center B cells. The more uniformly dense CD10-positive portion toward the lower-left corresponds to the dark zone, rich in proliferating centroblasts. The scattered individual pale “holes” throughout are mostly nonstaining tingible-body macrophages. The upper-right part of the germinal center is the light zone, and generally appears less densely CD10-positive because it contains more
1dmt: STRUCTURE OF HUMAN NEUTRAL ENDOPEPTIDASE COMPLEXED WITH PHOSPHORAMIDON
1r1h: STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS
In immunology, a centrocyte generally refers to a B cell with a cleaved nucleus, as may appear in e.g. follicular lymphoma. Centrocytes are B cells that are found in the light zones of germinal center
Neprilysin
…generally appears less densely CD10-positive because it contains more follicular dendritic cells and T-follicular-helper cells among the CD10-positive centrocytes. Acute lymphoblastic leukemia (ALL) cells are CD10+. Follicular lymphoma (follicle centre cell lymphoma) are CD10+. Burkitt Lymphoma cells are CD10…
Histopathology of centrocytes in a follicular lymphoma. They have a thick nuclear membrane and prominent nucleoli.
Histologic comparison of cell types in a germinal center, H&E stain: - Centrocytes are small to medium size with angulated, elongated, cleaved, or twisted nuclei. - Centroblasts are larger cells containing vesicular nuclei with one to three basophilic nucleoli apposing the nuclear membrane. - Follicular dendritic cells have round nuclei, centrally located nucleoli, bland and dispersed chromatin, and flattening of adjacent nuclear membrane.