Neustrelitz Hauptbahnhof is a railway station in the city of Neustrelitz, Mecklenburg-Vorpommern, Germany. The station lies on the Stralsund-Neubrandenburg railway, Neustrelitz–Warnemünde railway and Wittenberge–Strasburg railway. The train services are operated by Deutsche Bahn, DB Regio Nordost, and Hanseatische Eisenbahn.

The Berlin Northern Railway is a 223-kilometre-long main line route, that runs from Berlin via Neustrelitz and Neubrandenburg to Stralsund on the Baltic Sea coast. Nowadays, long-distance and regional traffic on the Nordbahn is routed at Hohen Neuendorf onto the Berlin Outer Ring to the Karower Kreuz and on to Berlin Main Station or Berlin-Lichtenberg.