New York State Route 15 (NY 15) is a north–south state highway located in western New York in the United States. The southern terminus of the route is officially at Interstate 390 (I-390) exit 3 south of the village of Wayland, although some signage indicating that NY 15 continues south to the northern terminus of U.S. Route 15 (US 15) in Painted Post still exists. The northern terminus of NY 15 is at an intersection with NY 31 in downtown Rochester. Outside of Monroe County, NY 15 is a rural two-lane highway. In the Rochester suburbs of Henrietta and Brighton, however, NY 15 is a major commercial strip, and the section in Rochester is a two-to-four lane street that serves commercial and residential areas.

Interstate 390 (I-390) is a 76.06-mile (122.41 km) north–south auxiliary Interstate Highway located entirely within New York in the United States. The southern terminus of the route is at the Southern Tier Expressway in the town of Avoca. Its northern terminus is at I-490 in Gates, just west of Rochester. North of I-490, the expressway continues as NY 390 to the Lake Ontario State Parkway in Greece. I-390 connects to its parent, I-90, in Henrietta, a southern suburb of Rochester. The route is known as the Genesee Expressway from Avoca to I-590 in Brighton, where it becomes part of the Rochester Outer Loop.