New York State Route 163 (NY 163) is an 11.97-mile-long (19.26 km) east–west state highway in Montgomery County, New York, in the United States. It runs in the shape of a C from an intersection with NY 5S and NY 80 in the village of Fort Plain to a junction with NY 10 in the town of Canajoharie. With the exception of its eastern terminus, NY 163 is not signed with directions. Reference markers indicate its terminus in Fort Plain to be its western, although the route heads nearly due southward until Sprout Brook. Approaching that hamlet, it is named Cherry Valley Road, and when NY 163 turns left to head eastward, County Route 82 (CR 82) continues that road name directly to NY 166 which leads to Cherry Valley. In Fort Plain, NY 163 follows Kellogg and Douglas streets. NY 163 is a two-lane highway for its entire length. The route was assigned as part of the 1930 renumbering of state highways in New York and originally continued north to the village of Canajoharie via NY 10.

New York State Route 80 (NY 80) is a 127.32-mile-long (204.90 km) west–east New York State Route located within Onondaga, Madison, Chenango, Otsego, Herkimer, and Montgomery counties in New York. Its western terminus is located at a junction with NY 175 in the city of Syracuse in Onondaga County, from which it actually runs in a north–south direction for 20 miles (32 km). The eastern terminus is located at a junction with NY 5 in the village of Nelliston in Montgomery County. The route is signed north–south from U.S. Route 20 (US 20) north to NY 5.