New York State Route 163 (NY 163) is an 11.97-mile-long (19.26 km) east–west state highway in Montgomery County, New York, in the United States. It runs in the shape of a C from an intersection with NY 5S and NY 80 in the village of Fort Plain to a junction with NY 10 in the town of Canajoharie. With the exception of its eastern terminus, NY 163 is not signed with directions. Reference markers indicate its terminus in Fort Plain to be its western, although the route heads nearly due southward until Sprout Brook. Approaching that hamlet, it is named Cherry Valley Road, and when NY 163 turns left to head eastward, County Route 82 (CR 82) continues that road name directly to NY 166 which leads to Cherry Valley. In Fort Plain, NY 163 follows Kellogg and Douglas streets. NY 163 is a two-lane highway for its entire length. The route was assigned as part of the 1930 renumbering of state highways in New York and originally continued north to the village of Canajoharie via NY 10.

New York State Route 5S (NY 5S) is a 72.92-mile-long (117.35 km) east–west state highway located in the Mohawk Valley of New York in the United States. It extends from a continuation of NY 5A at an interchange with I-790, NY 5, NY 8, and NY 12 in Utica to an interchange with I-890 and NY 890 in Rotterdam. The route runs along the south side of the Mohawk River for its entire length and parallels NY 5, which runs along the north side of the Mohawk River. NY 5S intersects several primary routes including NY 28 in Mohawk, NY 30A in Fultonville, NY 30 south of Amsterdam, as well as intersecting the New York State Thruway (I-90) several times. The route is part of New York State Bicycle Route 5 west of its junction with NY 103 in Schenectady County.