New York State Route 169 (NY 169) is a 12.42-mile-long (19.99 km) north–south state highway located within Herkimer County, New York, in the United States. It extends from an intersection with NY 5S in the town of Danube to a junction with NY 28 and NY 29 in the village of Middleville. The route connects the city of Little Falls to the New York State Thruway, which bypasses the city to the south. Outside of Little Falls, NY 169 is a two-lane highway that passes through sparsely developed areas.

New York State Route 5S (NY 5S) is a 72.92-mile-long (117.35 km) east–west state highway located in the Mohawk Valley of New York in the United States. It extends from a continuation of NY 5A at an interchange with I-790, NY 5, NY 8, and NY 12 in Utica to an interchange with I-890 and NY 890 in Rotterdam. The route runs along the south side of the Mohawk River for its entire length and parallels NY 5, which runs along the north side of the Mohawk River. NY 5S intersects several primary routes including NY 28 in Mohawk, NY 30A in Fultonville, NY 30 south of Amsterdam, as well as intersecting the New York State Thruway (I-90) several times. The route is part of New York State Bicycle Route 5 west of its junction with NY 103 in Schenectady County.