New York State Route 7 (NY 7) is a 180.30-mile-long (290.16 km) state highway in New York in the United States. The highway runs from Pennsylvania Route 29 (PA 29) at the Pennsylvania state line south of Binghamton in Broome County, New York, to Vermont Route 9 (VT 9) at the Vermont state line east of Hoosick in Rensselaer County. Most of the road runs along the Susquehanna Valley, closely paralleling Interstate 88 (I-88) throughout that road's length. Portions of the highway route near the cities of Binghamton, Schenectady, and Troy date back to the early 19th century.

Pennsylvania Route 29 is a 118-mile-long (190 km) north–south state highway that runs through most of eastern Pennsylvania.