Nisshōji Domain was a Fudai feudal domain under the Tokugawa shogunate of Edo period Japan. It was located in southeastern Ōmi Province, in the Kansai region of central Honshu. The domain was centered at Nisshōji jin'ya, located in what is now the town of Hino in Shiga Prefecture.

Ōmi Province was a province of Japan, which today comprises Shiga Prefecture. It was one of the provinces that made up the Tōsandō circuit. Its nickname is Gōshū (江州). Under the Engishiki classification system, Ōmi was ranked as one of the 13 "great countries" (大国) in terms of importance, and one of the "near countries" (近国) in terms of distance from the capital.