The Norte del Valle Cartel, or North Valley Cartel, was a drug cartel that operated principally in the north of the Valle del Cauca department of Colombia, most notably the coastal city of Buenaventura. It rose to prominence during the 1990s, after the Cali and Medellín Cartels fragmented, and it was known as one of the most powerful organizations in the illegal drug trade. The drug cartel was led by the brothers Luis Enrique and Javier Antonio Calle Serna, alias "Los Comba", until its takedown in 2008 by the authorities of Colombia and Venezuela, with cooperation of the United States DEA.

A drug cartel is a criminal organization composed of independent drug lords who collude with each other in order to improve their profits and dominate the illegal drug trade. Drug cartels form with the purpose of controlling the supply of the illegal drug trade and maintaining prices at a high level. The formations of drug cartels are common in Latin American countries. Rivalries between multiple drug cartels cause them to wage turf wars against each other.