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Nuclear lamina
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The nuclear lamina is a dense fibrillar network inside the nucleus of eukaryote cells. It is composed of intermediate filaments and membrane associated proteins. Besides providing mechanical support,
Confocal microscopic analysis of dermal fibroblasts in primary culture from a control (a and b) and the subject with progeria (c and d). Labelling was performed with anti-lamin A/C antibodies. Irregularly shaped nuclear envelopes are seen in many of the progeria fibroblasts.
Confocal microscopic analysis of dermal fibroblasts in primary culture from a control (a and b) and the subject with progeria (c and d). Labelling was
Structure and function of the nuclear lamina. The nuclear lamina lies on the inner surface of the inner nuclear membrane (INM), where it serves to mai
Structure and function of the nuclear lamina. The nuclear lamina lies on the inner surface of the inner nuclear membrane (INM), where it serves to maintain nuclear stability, organize chromatin and bind nuclear pore complexes (NPCs) and a steadily growing list of nuclear envelope proteins (purple) and transcription factors (pink). Nuclear envelope proteins that are bound to the lamina include nesprin, emerin, lamina-associated proteins 1 and 2 (LAP1 and LAP2), the lamin B receptor (LBR) and MAN1. Transcription factors that bind to the lamina include the retinoblastoma transcriptional regulator (RB), germ cell-less (GCL), sterol response element binding protein (SREBP1), FOS and MOK2.
Nuclear pore complex
Videos
The nuclear pore complex is a large protein complex giving rise to the nuclear pore. A great number of nuclear pores are studded throughout the nuclear envelope that surrounds the eukaryote cell nucle
Nuclear lamina
…regulates important cellular events such as DNA replication and cell division. Additionally, it participates in chromatin organization and it anchors the nuclear pore complexes embedded in the nuclear envelope. The nuclear lamina is associated with the inner face of the inner nuclear membrane of the nuclear envelope, whereas…
Scanning and illumination microscopy of nuclear pores, lamina, and chromatin.
Scanning and illumination microscopy of nuclear pores, lamina, and chromatin.