OSIRIS-REx was a NASA asteroid-study and sample-return mission that visited and collected samples from 101955 Bennu, a carbonaceous near-Earth asteroid. The material, returned in September 2023, is expected to enable scientists to learn more about the formation and evolution of the Solar System, its initial stages of planet formation, and the source of organic compounds that led to the formation of life on Earth. Following the completion of the primary OSIRIS-REx mission, the spacecraft is planned to conduct a flyby of asteroid 99942 Apophis, now as OSIRIS-APEX.

A sample-return mission is a spacecraft mission to collect and return samples from an extraterrestrial location to Earth for analysis. Sample-return missions may bring back merely atoms and molecules or a deposit of complex compounds such as loose material and rocks. These samples may be obtained in a number of ways, such as soil and rock excavation or a collector array used for capturing particles of solar wind or cometary debris. Nonetheless, concerns have been raised that the return of such samples to planet Earth may endanger Earth itself.