State Route 152 is the designation for two segments of a state highway in Jefferson County, Ohio. The southern segment, which is 6.18 miles (9.95 km) long, runs from SR 150 in Dillonvale to SR 151 in Smithfield. The northern segment, which is 20.20 miles (32.51 km) long, runs from an interchange with U.S. Route 22 (US 22) in Bloomingdale to SR 7 in Empire.

Jefferson County is a county located in the U.S. state of Ohio. As of the 2020 census, the population was 65,249. Its county seat is Steubenville. The county is named for Thomas Jefferson, who was vice president at the time of its creation.