State Route 219 is an east–west state highway in the western portion of the U.S. state of Ohio. State Route 219's western terminus is at the Indiana State Line approximately 5.5 miles (8.9 km) northwest of Fort Recovery, with the roadway continuing west into the Hoosier State being County Road 300N. The eastern terminus of State Route 219 is at a diamond interchange with Interstate 75 at its Exit 104 in Botkins.

Interstate 75 (I-75) runs from Cincinnati to Toledo by way of Dayton in the US state of Ohio. The highway enters the state running concurrently with I-71 from Kentucky on the Brent Spence Bridge over the Ohio River and into the Bluegrass region. I-75 continues along the Mill Creek Expressway northward to the Butler County line just north of I-275. From there, the freeway runs into the Miami Valley and then passes through the Great Black Swamp before crossing into Michigan.