Okfuskee County is a county located in the U.S. state of Oklahoma. As of the 2020 census, its population was 11,310. Its county seat is Okemah. The county is named for a former Muscogee town in present Cleburne County, Alabama, that in turn was named for the Okfuskee, a Muscogee tribe.

Okemah is the largest city in and the county seat of Okfuskee County, Oklahoma, United States. It is the birthplace of folk music legend Woody Guthrie. Thlopthlocco Tribal Town, a federally recognized Muscogee Indian tribe, is headquartered in Okemah. The population was 3,078 at the 2020 census, a 6.1 percent decline from 3,223 at the 2010 census.