Oklahoma's 4th congressional district is located in south-central Oklahoma and covers a total of 15 counties. Its principal cities include Midwest City, Norman, Moore, Ada, Duncan, Lawton/Ft. Sill, and Ardmore. The district also includes much of southern Oklahoma City.

Lawton is a city in and the county seat of Comanche County, in the U.S. state of Oklahoma. Located in southwestern Oklahoma, approximately 87 mi (140 km) southwest of Oklahoma City, it is the principal city of the Lawton, Oklahoma, metropolitan statistical area. According to the 2020 census, Lawton's population was 90,381, making it the sixth-largest city in the state, and the largest in Western Oklahoma.