Oliviero Carafa, in Latin Oliverius Carafa, was an Italian cardinal and diplomat of the Renaissance. Like the majority of his era's prelates, he displayed the lavish and conspicuous standard of living that was expected of a prince of the Church. In his career he set an example of conscientiousness for his contemporaries and mentored his relative, Giovanni Pietro Carafa, who became Pope Paul IV.

Pope Paul IV, born Gian Pietro Carafa, was head of the Catholic Church and ruler of the Papal States from 23 May 1555 to his death, in August 1559. While serving as papal nuncio in Spain, he developed an anti-Spanish outlook that later coloured his papacy. In response to an invasion of part of the Papal States by Spain during his papacy, he called for a French military intervention. After a defeat of the French and with Spanish troops at the edge of Rome, the Papacy and Spain reached a compromise: French and Spanish forces left the Papal States and the Pope thereafter adopted a neutral stance between France and Spain.