Once in a Lifetime is a three-CD box set by American post-punk/new wave band Talking Heads, released in the United States by Sire, Warner Bros, and Rhino in 2003. The set also includes a DVD containing an expanded version of the music video compilation Storytelling Giant. The discs are packaged in a wide horizontal book that recalls a CD longbox, featuring paintings by Russian artists Vladimir Dubossarsky and Alexander Vinogradov and with art direction by Stefan Sagmeister. Sagmeister would later work with David Byrne and Brian Eno on their 2008 collaborative album Everything That Happens Will Happen Today.

Stefan Sagmeister is an Austrian graphic designer, storyteller, and typographer based in New York City. In 1993, Sagmeister founded his company, Sagmeister Inc., to create designs for the music industry. He has designed album covers for Lou Reed, OK Go, The Rolling Stones, David Byrne, Jay Z, Aerosmith, Talking Heads, Brian Eno and Pat Metheny. From 2011 until 2019 he partnered with Jessica Walsh under the name Sagmeister & Walsh Inc.