One Oxford Centre is one of the major distinctive and recognizable features of Downtown Pittsburgh Pennsylvania, United States. The complex is named for Oxford Development, the developer and previous owner.

Downtown Pittsburgh, colloquially referred to as the Golden Triangle, and officially the Central Business District, is the urban downtown center of Pittsburgh, Pennsylvania, United States. It is located at the confluence of the Allegheny River and the Monongahela River whose joining forms the Ohio River. The triangle is bounded by the two rivers.