Op den Graeff is a German and American family of Dutch origin. They were one of the first families of the Mennonite faith in Krefeld at the beginning of the 17th century. Various family members belonged to Original 13, the first organized immigration of a closed group of Germans to America in 1683. There the family had a long history in religious service and politics, beginning in the late 17th century in the Colony of Pennsylvania. In 1688, they became forerunners of the anti-slavery movement by signing the first anti-slavery protest in North America. Their descendants spread into various lines, Updegraff, Uptegraft, Updegraft, Updegrave, Updegrove, Uptegrove, Ubdegrove, Uptegraph, Upthagrove. The Updegraff branch of Ohio belonged to the leading families of the Quaker religious movement and produced a long line of ministers and elders.

Krefeld, also spelled Crefeld until 1925, is a city in North Rhine-Westphalia, Germany. It is located northwest of Düsseldorf, its center lying just a few kilometers to the west of the river Rhine; the borough of Uerdingen is situated directly on the Rhine. Because of its economic past, Krefeld is often referred to as the "Velvet and Silk City". It is accessed by the autobahns A57 (Cologne–Nijmegen) and A44 (Aachen–Düsseldorf–Dortmund–Kassel).